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In preclinical and clinical studies, proteasome inhibitors have been shown to induce a growth arrest of GIST cells in the G1 phase of the cell cycle. This effect is associated with induction of apoptosis. In addition, the effectiveness of the proteasome inhibitors bortezomib and carfilzomib on GIST xenografts in mice was confirmed. These findings may provide a basis for the development of effective regimens for the treatment of patients with GISTs. In addition, the proteasome inhibitor carfilzomib has been shown to be effective in the treatment of patients with multiple myeloma (MM) who have failed previous therapy. The development of proteasome inhibitors for the treatment of patients with GIST may provide a new approach to the treatment of patients with GIST. 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